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Project Objectives
This project research objectives are:
  1. To develop an integrated model of the E. coli stress response system, focusing on the metabolic, genetic and signaling modules that regulate nitrogen and carbon source limitations.
  2. To develop mathematical methods for system reduction and approximation, in order to deal with large-scale models in which different time scales and many unknown parameter values occur.
  3. To develop parallel algorithms and prototype tools for exploring the models, predicting outcomes of experiments, and verifying specific properties at the model.
  4. To apply the developed methods and techniques to the E. coli stress response model in order to identify interesting properties, and to validate the model, by experimentally testing predicted properties in our laboratories.